WASHINGTON (AP) — Congress is bracing for President-elect Joe Biden to move beyond the Trump administration’s state-by-state approach to the COVID-19 crisis and build out a national strategy to fight the pandemic and distribute the eventual vaccine.

The incoming administration’s approach reflects Democrats’ belief that a more comprehensive plan, some of it outlined in the House’s $2 trillion coronavirus aid bill, is needed to get the pandemic under control. Republicans have resisted big spending but agree additional funding is needed. With the nation on edge but a vaccine in sight, the complicated logistics of vaccinating hundreds of millions of Americans raise the stakes on the major undertaking.

“We have an incredible challenge on our hands,” said Sen. Patty Murray of Washington state, which is approaching the anniversary of its first reported case of the virus last January.

A vaccine can only go so far, Murray warned, without a distribution plan. “A vaccine can sit on a shelf. A vaccination is what we’re talking about,” she said.

As Congress weighs a new round of COVID-19 relief, federal officials say doses of the vaccine could begin shipping within a day of Food and Drug Administration approval. Three pharmaceutical manufacturers — Pfizer, Moderna and AstraZeneca — have announced early results. But the rollout faces a patchwork of state plans, a transitioning White House and potential backlash from vaccine skeptics, despite the rising U.S. death toll of nearly 260,000 people.

Biden said Tuesday on NBC’s “Nightly News with Lester Holt” that his team has started meeting with COVID-19 officials at the White House on how to “get from a vaccine being distributed to a person being able to get vaccinated.”

Democrats have been sounding the alarm that the Trump administration’s delay in granting Biden’s team access to transition materials was wasting precious time.

States submitted draft vaccination planning documents last month, but not all of them have made full plans public. Private Capitol Hill briefings by officials from Operation Warp Speed, the federal vaccine effort, left some lawmakers fuming last week over what they called a lack of coordination with Biden’s camp.

Health and Human Services Secretary Alex Azar said Tuesday that his department “immediately” started working with Biden’s staff after the General Services Administration formally acknowledged the election results.

Azar said he wanted to ensure Biden’s transition would be “in the spirit of looking out for the health and well-being of the American people and, in particular, saving lives through this COVID-19 pandemic.”

From the start, the pandemic has challenged and reflected the two parties’ approaches to the public health crisis, with the Trump administration largely outsourcing many decisions to the states and Democrats pressing for a more nationalized approach.

In Congress, Republicans largely rejected the $2 trillion-plus House bill from Democrats as excessive. They prefer their own $500 billion Senate effort.